Sunday, May 3, 2015

Recent Advances: Phage Therapy for Antibiotic Resistant Staph Infections

MRSA is an antibiotic resistant form of
Staphylococcus aureus, and a big problem
for hospitals. <SOURCE>

Introduction

Most of us have experienced, know someone who experienced, or have at least heard of Staph infections. As their name implies, these infections are caused by Staph (short for the bacterial genus Staphylococcus), occur on the skin, are often acquired in hospitals, and are an increasing problem as the bacteria become increasingly antibiotic resistant. One of the most famous of these bacteria is Methicillin Resistant Staphylococcus aureus (MRSA), which is resistant to many of the antibiotics normally used to treat Staph infections. As antibiotic resistance continues to be a problem, researchers and clinicians are looking to new antibiotics, as well as antibiotic alternatives. One of these alternatives is phage therapy.

We have talked about phage therapy before (click here to read more), so I will not go through it again in detail here. I will only recap by saying that phage therapy is the use of bacteriophages (bacterial viruses; phages for short) as therapeutics to treat bacterial infections. This involves administration of concentrated phages to the infection, which results in the phage infection and consequent death of those bacteria. A research article discussing phage therapy against Staph infections was recently published in PLOS ONE, and because I think phage therapy is ultra cool, I wanted to discuss it in this post. My goal for this post is to give you a brief summary of the paper, as well as some insights and perspectives about the paper and phage therapy as a whole.

The Main Points of the Paper

  • Researchers are focusing on testing a single, commercially available research phage as a therapeutic against a single MRSA strain.
  • Phage treatment of Staph infected mice resulted in reduced lesion size, but failed to reduce the bacterial counts.
  • Responses to the phage therapy (immune responses, lesion size, and bacterial counts) were dose dependent.
  • While the phage therapy limited Staph bacterial growth in artificial media culturing conditions, the therapy was not effective in human blood culture. This was the result of the blood limiting bacterial growth alone, before the phage therapy was added.
  • The selected phage therapy exhibited limited tropism, meaning it was unable to kill many strains of bacteria.
  • The phage therapy presented no significant preclinical safety concerns.

A Little More Discussion

Bacteriophages (shown in green) can infect a bacteria,
replicate inside of it, burst out killing the host, and repeat
the process. <SOURCE>
So in the end, the paper is a pretty good, standard characterization of another potential phage therapy. One important point the authors brought up was the limited tropism of their selected bacteriophage. Many phages are limited in the numbers of different bacterial strains that they can infect, which becomes a therapeutic problem. To ensure the efficacy of the therapy, the clinician would have to be absolutely sure of the bacterial strain, which is not clinically feasible. A way around this would be to create a phage cocktail instead of a single phage therapy, but this becomes a small molecule regulatory issue because every phage would still have to be tested for safety and efficacy individually before it can be added to a cocktail. The authors suggest labeling phage therapies under different regulatory guidelines, which I think is a fair point. As I mentioned a couple of weeks ago, labeling phage therapies as types of probiotics, similar to what is being done with the fecal microbiome transplants, could be a fruitful path.

I think that this tropism point is also important because it highlights the need for screening phage therapy candidates for broad tropism. A relatively small subset of phages have broad tropism, meaning they are able to target a wide variety of bacteria. Finding and using these phages as therapeutic candidates would likely minimize the tropism issues experiences by the authors of this paper, as well as the countless other researchers who experience this problem.

Another point the authors did not address, that I think is very important, is the neutralizing human or mouse immune response to the phage therapy. A significant problem in gene therapy is that the virus vector (the virus that delivers the therapy) becomes the target of an immune response, which effectively vaccinates the patient against the therapy and prevents re-administration. It seems very likely that this could occur in the phage therapy setting as well, and previous studies have indeed suggested this occurs. It would have been interesting to see whether the mice used in this study experienced such a vaccination response. This is going to have to be an important point for future researchers that investigate phage therapeutics.

ResearchBlogging.org

WORKS CITED




Pincus, N., Reckhow, J., Saleem, D., Jammeh, M., Datta, S., & Myles, I. (2015). Strain Specific Phage Treatment for Staphylococcus aureus Infection Is Influenced by Host Immunity and Site of Infection PLOS ONE, 10 (4) DOI: 10.1371/journal.pone.0124280



43 comments:

  1. AM KELLY EBE, THHANKS TO DR OSAZE WHO CURD ME OF STAPHYLOCOCUS AND BACTERIA INFECTION.
    I SUFFERERD FOR STAPHYLOCOCUS FOR OVER FIVE AND HALF YEARS, I WENT TO DIFFERENT HOSPITALLS AND DIFFERENT HERBAL HOMES, TO NO AND VEIL, UNTIL A FRIEND RECOMMENDED DR OSAZE HERBAL HOME TO ME, AND HE ADMINISTERERD HIS HERBAL MEDICATION ON ME, WITHIN THREE WEEKS AND SOME DAYS I WAS CURED.
    IN CASE YOU ARE SEFFRING FOR A SIMILAR DIESEASE, YOU CAN ALSO REACH DR OSAZE FOR SIMILAR TREATMENT ON +2347089275769 OR EMAIL DROSAZE39@GMAIL.COM

    ReplyDelete
    Replies
    1. Having herpes is not the end of life there many treatment to cure herpes infection with the help of Dr Edidia herbal product.
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    2. Hello viewer’s
      I don’t have much to say there are so may scammers going on online so we cant detect the real herbal medicine doctors. Thank GOD for leading me, please don’t ignore this post is real Dr Emmanuel, is a real herbal Doctor, he cured me from Herpes virus, i am living so happy and free , i was fully recovered within 4 weeks of usage of dr Emmanuel herbal medicine ,please viewers out there that have any deadly disease don't fail to contact him via his email; nativehealthclinic@gmail.com or WhatsApp/Call: +2348140073965 thanks once again to dr Emmanuel GOD bless you abundantly

      Delete
    3. THANKS TO DR ONIHA WHO CURED ME AND MY HUSBAND OF FIVE YEARS STAPHYLOCOCUS INFECTION.
      WE SUFFERED STAPH INFECTION FOR OVER FOUR YEARS, WE WENT TO ALMOST ALL THE HOSPITAL IN TOWN, TO NO AND VAIL, WE EVEN TOOK SO MANY ANTIBIOTICS WHICH DID NOT YIELD ANY MEANIFUL RESULT, UNTIL A FRIEND RECOMMENDED DR ONIHA'S HERBAL MEDICATION TO ME, AND WE GAVE IT A TRY, WITHIN A MONTH AND A WEEK, WE WERE BOTH CURED COMPLETELY OF STAPHTLOCOCUS.
      IN CASE YOU ARE PASSSING THROUGH SIMILAR PROBLEM, AND YOU NEED DR ONIHA'S ASSISTANCE, YOU CAN CALL OR WHATSAP HIM ON +2347089275769 OR EMAIL: DRONIHASPELL@YAHOO.COM

      Delete
    4. I am celebrating today because God uses Dr Keghor to bring smile on my face and that of my wife, I was diagnosed of staphylococci MRSA 4 years ago, i tried everything i could to eradicate the sickness it's prove abortive, these infection resist all antibiotics. Hospital now become our second home because we always fall sick in addition we were having wounds all over our body including my nose. One day i came across one Aisha Bello from Malaysia online he was testifying on how she was cure from these same infection after using Dr Keghor herbs that i and my wife is suffering from, without wasting time i contacted Dr Keghor for advice and he assured me within three weeks i and my wife will be cure and i order for the wonderful medication after applying the medication for that said weeks my wounds started healing behold my wife and i was cured totally after series of check up. I am so excited and i decide to express my joy publicly. If you are suffering from these same infection or any other virus of any kinds, you can reach Dr Keghor on his email drkeghor049@gmail.com, call or Whatsapp him on +2348022561006

      Delete
    5. Having herpes Disease is not the end of life,there are treatment to cure herpes disease with the help of Dr Oso herbal medicine. I have been suffering from this deadly disease called herpes disease (HSV) and i lost hope because I was not myself anymore it was not easy working with herpes disease, i searched online to know and enquirer about cure for kidney and i read someone testimony on how he was cured from kidney disease, I don't believe it's true, but I decided to give a try to no if it will really work out for me so i contacted him to know how he can help me and he told me never to worry that he will help me with the natural herbs from God! after 2 days of contacting him, he told me that the cure has been ready for me and he sent it to me via FedEx and it got to me in 3 days! i used the medicine as he instructed me (MORNING and EVENING) after using the medication for few weeks I started experiencing change inside my body, could you believe as I finish the medication I was totally healed It's really like a dream but i am so happy!that's the reason i decided to also add more comment of Him so that more canbe saved just like me! You can contact him via drosohaberhome@gmail.com or test/WhatsApp +2348162084839 =====
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    6. i already gave up on ever getting cured of HSV2 because i have try many treatment none of them work out for me i have go to different hospital they always tell me same thing there is no cure for herpes when i came across a post about Dr ohunyom, in the net from a lady called Angela i contacted him and he reassured me with him herbal medicine which i took according to the way he instructed, that how i was cured. I doubted at first because i have been to a whole lot of reputable doctors, tried a lot of medicines but none was able to cure me. so i decided to listen to him and he commenced treatment, and under two weeks i was totally fee from #Herpes. i want to say a very big thank you to DR ohunyom for what he has done in my life. feel free to leave him a message on email drohunyom@gmail.com and also WhatsApp him +2349060579973..
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    7. I'm here to testify about the great work Dr okosun did for me. I have been suffering from (HERPES) disease for the past 4 years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulating all over my body and i have been taking treatment from different doctors, few weeks ago i came across lots of testimonies from different people on a particular doctor on the internet called Dr okosun on how he cured various people from Herpes Simplex Virus and other diseases. i took the email address of this man from one of the testifiers advising anybody to contact him for help for any kind of sickness that he would be of help, so I emailed him telling him about my (HERPES Virus) he told me not to worry that i was going to be cured! , well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as Dr okosun assured me that i will be cured,after four week of taking his medication as told by dr okosun, i went to my doctor for herpes virus check up and behold i was declared negative, i also waited for a week and went to another hospital for another check up to be be truly sure and behold i was still declared herpes negative, And i want to use this opportunity to tell those people out there secretly suffering from herpes or other diseases should contact dr okosun and get cured. you can get in touch with this doctor via email : drokosun55@gmail.com. You can also whatsapp him +2348124363791. Thanks once again Dr okosun god bless you



      Delete
    8. I Never believed i was ever going to be HSV FREE again, DR.Ehiaguna has given me reasons to be happy, i was HSV positive for 2 years and all the means and medicine i tried for treatment was not helpful to me, but when i came on the Internet i saw great testimony about DR.Ehiaguna on how he was able to cure someone from HSV 2, this person said great things about this man, and advice we contact him for any Disease problem that DR.Ehiaguna can be of help, well i decided to give him a try, he requested for my information which i sent to him, and he told me he was going to prepare for me a healing portion, which he wanted me to take for days, and after which i should go back to the hospital for check up, well after taking all the treatment sent to me by DR.Ehiahuna , i went back to the Hospital for check up, and now i have been confirmed HSV NEGATIVE, friends you can reach DR.Ehiaguna on any treatment of any Disease cos i saw many testimony of different disease like, HEPATITIS,HIV AIDS,EPILEPSY, CANCER,CFS he is the one only one i can show you all up to, reach him on drehiaguna@gmail.com or whatsApp him now +2348073908953. quick contact him for help and you can just quickly drop your number on your first mail as i did for easily conversation

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  2. Hello everyone. I was heartbroken because i had very small penis, not nice to satisfy a woman, i had so many relationship called off because of my situation, i have used so many product which i found online but none could offer me the help i searched for. i saw some few comments about this doctor called Dr. OMOHAN and I decided to email him on: dromohanherbalmedicine@gmail.com so I decided to give his herbal product a try. i emailed him and he got back to me, he gave me some comforting words with his herbal cream for Penis Enlargement, Within 1 week of it, i began to feel the enlargement of my penis, " and now it just 2 weeks of using his products my penis is about 9 inches longer and strong. I'm so happy..feel free to contact DR OMOHAN on his Email: dromohanherbalmedicine@gmail.com or you can also call him on the whatsapp contact +2348164816038

    ReplyDelete
  3. am shadrack from ohio, thanks to dr osaze who cured me of staphiococos and FUNGAI INFECTION.
    i was having these sickness for over four years, i took so many anthibiotis injections in the hospital, all to no and vail,the saph resisted all medical treatment, until i read about dr osaze's herbal home healing center, on how he has cured so many people of this same ilness, and i surmon courage to contact him, and he sent me the herbal mmedication, after taking the medication for three weeks i was cured.
    incase you wants to contact him for a similar ilness, you can reach him thriugh his phone number +2347089275769 or email: drosaze39@gmail.com

    ReplyDelete
  4. Hi everyone, I am ANDREW JOY, from , USA . I am publicizing this amazing testimonial of my life on this forum because i knew of so many people who will still be having this same issues, which you are finding so difficult to solve. I have been suffering from HIV for the past 2 years.I have visited doctors but they couldn't get the permanent solution to my sickness. I almost loosed it until one faithful day when i saw so many amazing testimonials about DR UDO how he has cured patients infected with HIV. So i decided to give it a try and contact him, here i am now. All thanks to DR UDO for curing my HIV permanently. Now i am perfectly fine, and i am HIV negative. you too can get cured today by contacting his email address now at udoherbalhome@gmail.com or whatsapp him on +2347031128033 Thanks so much

    ReplyDelete
  5. Hello Everybody,
    My name is Mrs Sharon Sim. I live in Singapore and i am a happy woman today? and i told my self that any lender that rescue my family from our poor situation, i will refer any person that is looking for loan to him, he gave me happiness to me and my family, i was in need of a loan of $250,000.00 to start my life all over as i am a single mother with 3 kids I met this honest and GOD fearing man loan lender that help me with a loan of $250,000.00 SG. Dollar, he is a GOD fearing man, if you are in need of loan and you will pay back the loan please contact him tell him that is Mrs Sharon, that refer you to him. contact Dr Purva Pius,via email:(urgentloan22@gmail.com) Thank you.

    ReplyDelete
  6. Hello Everybody,
    My name is Mrs Sharon Sim. I live in Singapore and i am a happy woman today? and i told my self that any lender that rescue my family from our poor situation, i will refer any person that is looking for loan to him, he gave me happiness to me and my family, i was in need of a loan of $250,000.00 to start my life all over as i am a single mother with 3 kids I met this honest and GOD fearing man loan lender that help me with a loan of $250,000.00 SG. Dollar, he is a GOD fearing man, if you are in need of loan and you will pay back the loan please contact him tell him that is Mrs Sharon, that refer you to him. contact Dr Purva Pius,via email:(urgentloan22@gmail.com) Thank you.

    ReplyDelete
  7. MY HERPES DISEASE WAS CURED BY PROPHET Jennifer, WITH HIS HERBAL HEALING TREATMENT (Dr.airehome@gmail.com ).(+2347036740271
    DR Aire is the only Dr who could ever
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    day I was just browsing on the internet when I come across a great
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    see that at the very day which he said I will be healed, all the
    strength that has left me before rush back and I becomes very strong
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    said I'm alright now , I am very amazed and happy about the healing
    Dr Aire gave to me and this my mail if you need more information
    drairehome@gmail.comand he also cure all manner of diseases

    ReplyDelete
  8. Hello everyone, I was infected with the Epstein-Barr virus and I got cured from the Epstein-Barr virus few months ago after i contacted Chief Dr Lucky. I saw a post on the internet after i have seek healing for several years from different doctors in California. I sent the Doctor a request for help, just a few email i followed his instruction and he sent me the medication. Now i am negative and i referred him to all my friend who had this same sickness and they have gotten their cure too.
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    ReplyDelete

  9. I'm here to testify about what DR. Afrid did for me. I have been suffering from (HERPES) disease for the past 5 years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulating all over my body and i have been taking treatment from my doctor, few weeks ago i came across a testimony of one lady on the internet testifying about a Man called DR. Afrid on how he cured her from herpes disease. And she also gave the email address of this man and advise anybody to contact him for help for any kind of sickness that he would be of help, so I emailed him telling him about my (HERPES) he told me not to worry that i was going to be cured!! Well i never believed it well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as DR. Afrid assured me that i will be cured,after some time i went to my doctor to confirmed if i have be finally healed behold it was TRUE, the test came out negative. So friends my advise is if you have such sickness or any other at all you can contact DR. Afrid for help via email{ drafridhaberbalhome@gmail.com} CALL/WHATSAPP HIM +2349057260738.

    ReplyDelete
  10. Are you going through STAPHYLOCOCCUS? Doctor Uduehi is your best bet and I am a testimony to his great herbal cure. I suffered staphylococcus aureus for more than a year, and not too long ego I read about Dr. Uduehi’s recommendation online and after taking his medication all pains were gone. I ran 2 test and they both proof negative which means I am cured and free. Reach him through Email: uduehiherbalcare@gmail.com phone/WhatsaPP:+2347084878384

    ReplyDelete
  11. Hello viewer’s
    I don’t have much to say there are so may scammers going on online so we cant detect the real herbal medicine doctors. Thank GOD for leading me, please don’t ignore this post is real Dr Emmanuel, is a real herbal Doctor, he cured me from Herpes virus, i am living so happy and free , i was fully recovered within 4 weeks of usage of dr Emmanuel herbal medicine ,please viewers out there that have any deadly disease don't fail to contact him via his email; nativehealthclinic@gmail.com or WhatsApp/Call: +2348140073965 thanks once again to dr Emmanuel GOD bless you abundantly

    ReplyDelete
  12. AM TINA, THANKS TO DR ONIHA WHO CURED ME AND MY HUSBAND OF FIVE YEARS STAPHYLOCOCUS INFECTION.
    WE SUFFERED STAPH INFECTION FOR OVER FOUR YEARS, WE WENT TO ALMOST ALL THE HOSPITAL IN TOWN, TO NO AND VAIL, WE EVEN TOOK SO MANY ANTIBIOTICS WHICH DID NOT YIELD ANY MEANIFUL RESULT, UNTIL A FRIEND RECOMMENDED DR ONIHA'S HERBAL MEDICATION TO ME, AND WE GAVE IT A TRY, WITHIN A MONTH AND A WEEK, WE WERE BOTH CURED COMPLETELY OF STAPHTLOCOCUS.
    IN CASE YOU ARE PASSSING THROUGH SIMILAR PROBLEM, AND YOU NEED DR ONIHA'S ASSISTANCE, YOU CAN CALL OR WHATSAP HIM ON +2347089275769 OR EMAIL: DRONIHASPELL@YAHOO.COM

    ReplyDelete
  13. i have been trying to get pregnant for over 5 years now. My husband and I have been seeing a fertility specialist. We have done our best but no luck. My husband has a sperm count which goes up and down,the doctor has recommended him taking the Proceed supplement which he is doing over 3 years with no change in the situation .. I was so confused until i contacted this powerful spell caster Dr. Osemuhau online who I saw a number of testimonies of how he has help so many of people so I sent Dr. Osemuhau a mail and I told him all my sorrows and pain he replied me and ask me not to cry any more that he will help, he sent me some instructions and caution, Dr. Osemuhau cast the spell and I bought some items to complete the spell casting and he told me to meet with my husband.. Within 3weeks of doing this I felt some changes and I went to my doctor and it was confirm that I was pregnant,i promises Dr Osemuhau to share his testimony for three years,it has been over a year and four months now,i have been testifying this great testimonies for my life and my husband,for any one how need his help herb potion should contact him,on his Email [ drosemuhau@gmail.com ] or call him on [ +2348168714427 ]

    ReplyDelete
  14. I was despondent because i had a very small penis, about 2.5 inches soft and 4 inches hard not nice enough to satisfy a woman, i have been in so many relationship, but cut off because of my situation, i have used so many product which doctors prescribe for me, but none could offer me the help i searched for. i saw some few comments on the INTERNET about this specialist called Dr movo and decided to contact him on his email: {drmovo.supernaturalherbalmedic@gmail.com} so I decided to give his herbal product a try. i emailed him and he got back to me, he gave me some comforting words with his herbal pills for Penis Enlargement, Within 3 week of it, i began to feel the enlargement of my penis, " and now it just 4 weeks of using his products my penis is about 9 inches longer, and i had to settle out with my Ex girlfriend JOY, i was surprised when she said that she is satisfied with my sex and i have got a large penis. Am so happy, thanks to Dr movo I also learn that Dr movo also help with Breast Enlargement Hips and Bums Enlargement etc.. If you are in any situation with a little Penis, weak ejaculation, small breast_hips_bums do get to Dr movo now for help on his email:{drmovo.supernaturalherbalmedic@gmail.com} or whatsapp +2347061865209).

    ReplyDelete
  15. Natural cures for herpes have been in existence before the first Olympian threw a disc or ran a race. Modern Medicine came in like a conquering hero and all the old remedies were soon forgotten and swept under the rug. It wasn't until someone investigated all the possibilities and combinations of ancient remedies that many of the natural cures became popular.I Linda Donna, I was herpes patient for two year and have taken different prescription of drugs or medicine but there was no cure i became very sick and frustrated also, Until my friend saw and read a testimony of a lady on this blog on who was cured of HIV~aids by Dr Akhigbe. With his herbal remedies cure, We contacted him through his email, drrealakhigbe@gmail.com He reply us and told us what to do, He prepared the herbal medicine and send it to me through Dhl courier services, and instructed me how i will be taking it. My grated surprise is getting to three weeks my herpes get cure totally. Brother and sister Dr Akhigbe herbal remedies cure is very powerful. I have to testify him here so that everyone can get the information here.Dr Akhigbe also cure diseases like,. DIABETES,ALS,HIV~AIDS,CANCER, FIBROID,HERPES ,HEPATITIS..In case you are there and you need his help please contact his email, drrealakhigbe@gmail.com or WhatApp HIM ON +2348142454860

    ReplyDelete
  16. I'm here to testify about the great work Dr ogden did for me. I have been suffering from (HERPES) disease for the past 5 years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulating all over my body and i have been taking treatment from my doctor, few weeks ago i came across a testimony of one lady on the internet testifying about a Man called Dr ogden on how he cured her from Herpes Simplex Virus. And she also gave the email address of this man and advise anybody to contact him for help for any kind of sickness that he would be of help,so I emailed him on drogdentestimony@gmail.com telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! Well i never believed it,, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as Dr ogden assured me that i will be cured,after some time i went to my doctor to confirmed if i have be finally healed behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can contact Dr ogden via email drogdentestimony@gmail.com You can also call or whatsApp his telephone number on +2348117963221.Thanks once again Dr ogden

    ReplyDelete
  17. Hello everyone i Am Ben Mark and i am from USA i am here to give my testimony about an herbal doctor called Dr,Akioya I was heartbroken because i had very small penis,not nice to satisfy a woman, i have been in so many relationship, but cut off because of my situation, i have used so many product which doctors prescribe for me, but could not offer me the help i searched for. i saw some few comments on the internet about this specialist called Dr,Akioya and decided to email him on his email i saw on the internet,(drakioya17spellhome@gmail.com ) so I decided to give his herbal product a try. i emailed him and he got back to me, he gave me some comforting words with his herbal product for Penis Enlargement, Within three weeks of me use it, i began to feel the enlargement, " and now it just 4 weeks of using his products my penis is about 8 inches longer, and i had to settle thing out with my ex girlfriend , i was surprised when she said that she is satisfied with my performance in bed and i now have a large penis.thanks to DR Akioya for is herbal product. you can also reach him with emsil drakioya17spellhome@gmail.com though is..number WHATASPP him today on this number [ +2348105257464 ] you can checkout is website; http://drakioyaherbalcenter.home.blog
    https://drakioyaherbalhome.blogspot.com/

    ReplyDelete
  18. Hello everyone. I was heartbroken because i had very small penis, not nice to satisfy a woman, i had so many relationship called off because of my situation, i have used so many product which i found online but none could offer me the help i searched for. i saw some few comments about this doctor called Dr Udi and I decided to email him on: drudiherbalhome@gmail.com so decided to give his herbal product a try. i emailed him and he got back to me, he gave me some comforting words with his herbal cream for Penis Enlargement, Within 1 week of it, i began to feel the enlargement of my penis, " and now it just 2 weeks of using his products my penis is about 9 inches longer and strong. I'm so happy..feel free to contact Dr Udi on his Email: drudiherbalhome@gmail.com or you can call or what-app him +2348051243538 or you can check out his website
    https://drudiblogaddress.blogspot.com/
    https://drudiherba.home.blog:

    ReplyDelete
  19. HOW I GOT CURED OF HERPES VIRUS.

    Hello everyone out there, i am here to give my testimony about a herbalist called dr imoloa. i was infected with herpes simplex virus 2 in 2013, i went to many hospitals for cure but there was no solution, so i was thinking on how i can get a solution out so that my body can be okay. one day i was in the pool side browsing and thinking of where i can get a solution. i go through many website were i saw so many testimonies about dr imoloa on how he cured them. i did not believe but i decided to give him a try, i contacted him and he prepared the herpes for me which i recieved through DHL courier service. i took it for two weeks after then he instructed me to go for check up, after the test i was confirmed herpes negative. am so free and happy. so, if you have problem or you are infected with any disease kindly contact him on email--- drimolaherbalmademedicine@gmail.com. or / whatssapp --+2347081986098.
    This testimony serve as an expression of my gratitude. he also have herbal cure for COLD SORE, SHINGLES, CANCER, HEPATITICS A, B. DIABETES 1/2, HIV/AIDS, CHRONIC PANCERATIC, CHLAMYDIA, ZIKA VIRUS, EMPHYSEMA, LOW SPERM COUNT, ENZYMA, COUGH, ULCER, ARTHRITIS, LEUKEMIA, LYME DISEASE, ASTHMA, IMPOTENCE, BARENESS/INFERTILITY, WEAK ERECTION, PENIS ENLARGEMENT. AND SO ON.

    ReplyDelete
  20. I want to share my testimony on how i get cure of my HERPES GENITAL with
    the help of Doctor idahosa, i have being suffering for this disease for a
    very long time now.i have try several means to get rid of of the (HERPES)
    disease for the last five years and had constant pain, especially in my
    knees. During the first year,I had faith in God that i would be healed
    someday.This disease started circulate all over my body and i have been
    taking treatment from my doctor, few weeks ago i came on search on the
    internet if i could get any information concerning the prevention of this
    disease, on my search i saw a testimony of someone who has been healed from
    (Hepatitis B and Cancer) by this Man Dr idahosa and she also gave the email
    address of this man and advise we should contact him for any sickness that
    he would be of help, so i wrote to Dr idahosa telling him about my (HERPES
    Virus) he told me not to worry that i was going to be cured!! hmm i never
    believed it,, well after all the procedures and remedy given to me by this
    man few weeks later i started experiencing changes all over me as the
    Doctor assured me that i am cured,after some time i went to my doctor to
    confirmed if i have be finally healed behold it was TRUE, So friends my
    advise is if you have such sickness or any other at all you can email Dr
    idahosa on { dridahosasolutioncenter@gmail.com } sir i am indeed grateful
    for the help i will forever recommend you to my friends and to share this
    to every one that have any of this sickness you can call his whatssAp via
    +2348134261542

    ReplyDelete
  21. HELLO EVERYONE.. FEW MUNINETS TO REDY THIS INFOR ON HERPES CURE 2018..
    2017 MY MOTHER WAS DIAGNOSED OF HERPES/ KNOWN AS GENITAL WARTS ,I SPENT A LOT OF MONEY ON HER MEDICATION TILL A POINT I EVEN LOST HOPE,BECAUSE MY MOTHER WAS GRADUALLY DYING AND LOST HER MEMORY TOO, I WAS SO DESPERATE TO GET MY MOTHER BACK TO NORMAL, ONE DAY MY UNCLE WHO LIVES IN LONDON UNITED KINGDOM TOLD ME ABOUT DR OLIHA ,WHO HELPED HIM GET RID OF HERPES /GENITAL WART WITH HERBAL MEDICINE AND HIS HERBAL SOAP ,I WAS SO SHOCKED WHEN HE TOLD ME ABOUT THIS ,ALTHOUGH I NEVER BELIEVE IN HERB BUT, I KEEP TO BELIEVE BECAUSE MY UNCLE CAN'T TELL ME LIES WHEN IT COMES TO HEALTH CONDITION I CONTACTED DR OLIHA VIA HIS EMAIL; OLIHA.MIRACLEMEDICINE@GMAIL.COM , YOU CAN TALK TO HIM VIA CALL OR WHATSAPP MESSENGER ON +2349038382931 , HE REPLIED AND ASK ME TO SEND MY HOME ADDRESS AND MY MOTHER'S DETAIL AND THEN I PURCHASED THE HERBAL MEDICINE,SENT ME THE HERBAL MEDICINE THROUGH COURIER SERVICE, WHEN I RECEIVED THIS HERBAL MEDICINE USED IT FOR 2 WEEKS, AND 4 DAYS OF USAGE THE WARTS FELL OFF, MY MOTHER I NOW TOTALLY CURED AND MY MOTHER IS LIVING FREE AND HAPPY AGAIN. YOU CAN TALK TO DR VIA HIS MOBILE NUMBER OR WHATS APP HIM ON +2349038382931.ALL THANKS TO DOCTOR DR OLIHA

    ReplyDelete
  22. Dr ITUA is real I was suffering from HERPES Simplex Virus, i
    was totally depressed due to my predicament , until i meet Dr
    ITUA the great Traditional healer who cured me. you can
    also contact him now on whats app +2349078751746
    or via email:drituaodigie@gmail .com for more
    information. The medicine has NO SIDE EFFECT, there's no
    special diet when taking the medicine. He also has cure for
    SHINGLES ECZEMA, URETHRA, WART, HIV AIDS ALS,
    HEPATITIS B, CANCER, HERPES, DIABETES ULCER and lots
    more.

    ReplyDelete
  23. God bless Dr. Momoh for his marvelous work in my life, I was diagnosed of HIV since 2010 and I was
    taking my medications, I wasn't satisfied i needed
    to get the HIV.out of my system, I searched about
    some possible cure for HIV i saw a comment about, how he cured HIV with his herbal
    medicine, I contacted him and he guided me.I
    asked for solutions, he started the remedy for my
    health, he sent me the medicine through UPS SPEED
    POST.I took the medicine as prescribed by him
    and 14 days later i was cured from HIV, thank you so much and you are the one that God sent to change my miserable life, you the almighty god be with you all the days of your life, so my brothers and sisters we cancontact him on this email address.dr.momoh9@gmail.com or whatsapp him on +2347083724098 Dr momoh ONCE AGAIN
    THANK YOU SIR.
    Dr momoh he also told me that he can cure the flowing virus,
    1 cancer cure
    2 diabetes cure
    3 ringing ear
    4 herpes cure
    5 warts cure
    6 HPV cure
    7 get your ex back
    8 pregnancy herbal medicine
    9 prostate enlargement
    10 Hepatitis B

    ReplyDelete
  24. Having herpes Disease is not the end of life,there are treatment to cure herpes disease with the help of Dr Oso herbal medicine. I have been suffering from this deadly disease called herpes disease (HSV) and i lost hope because I was not myself anymore it was not easy working with herpes disease, i searched online to know and enquirer about cure for kidney and i read someone testimony on how he was cured from kidney disease, I don't believe it's true, but I decided to give a try to no if it will really work out for me so i contacted him to know how he can help me and he told me never to worry that he will help me with the natural herbs from God! after 2 days of contacting him, he told me that the cure has been ready for me and he sent it to me via FedEx and it got to me in 3 days! i used the medicine as he instructed me (MORNING and EVENING) after using the medication for few weeks I started experiencing change inside my body, could you believe as I finish the medication I was totally healed It's really like a dream but i am so happy!that's the reason i decided to also add more comment of Him so that more canbe saved just like me! You can contact him via drosohaberhome@gmail.com or test/WhatsApp +2348162084839 =====
    Once again thank you so much Dr oso may God bless you abundantly, I'm forever grateful ..    

    here is the  DR OSO website. https://sites.google.com/view/drosohaberhome/
    His blog page https://drosohaberhome.blogspot.com

    you can also email me for more information about DR oso via smithmorgan2777@gmail.com ALL THANK TO DR OSO .

    ReplyDelete
  25. Life has not been so easy for me, i almost gave up on getting cured of HSV2 because i have tried many treatment and still don't work for me, so i was going place to place just for me to search for herbs cure or any solution to my problem and i also have three kids to take care of, that same period my husband die in an accident on it way coming home so life was very tough for me, so when i was going through the herbs site to find a cure for my problem i saw a story about a lady testify about DR.Imoudu, so i said to my self let me give a try to see if my problem can be solved, because i have spend alot of money In the hospital and their was no cure for it, so i contacted DR.Imoudu that afternoon of it and he gave me instruction how i will go about it and he sent me a herbal medicine which I took according to the way he instructed me to do. After taking the medicine for two weeks i saw a changes on my body, then i called the Dr and told him about it and he said i should go for test. i can't believe when my result came out it was negative, i was very happy to share this great testimony to the world there is real cure for #herpes you can also contact DR.Imoudu Email: DR.IMOUDUHEALERTEMPLE@GMAIL. COM also WhatsApp him +2348109609753..
    He also have herbs medicine to cured the following diseases;
    Diabetes, Lupus, Gout, Hepatitis A,B, Infertility, HIV/AIDS, CANCER, WART,ALS CURE/DIABETES CURE/EPILEPSY/HPV CURE/LOOSE WEIGHT AND BODY/EX-BACK/stroke

    ReplyDelete
  26. I am so Happy to be writing this article in here, i am here to explore
    blogs forum about the wonderful and most safe cure for HERPES SIMPLEX VIRUS
    . I was positive to the deadly Virus called HERPES and i lost hope
    completely because i was rejected even by my closet friends. i searched
    online to know and inquire about cure for HERPES and i saw Dr Godwin
    testimony online on how he was cured so many persons from Herpes Disease so
    i decided to contact the great herbalist because i know that nature has the
    power to heal everything. i contacted him to know how he can help me and he
    told me never to worry that he will help me with the natural herbs from
    God! After 2 days of contacting him, he told me that the cure is ready and
    he will send it to me via FEDEX or DHL and it will get to me after 4 days!
    i used the medicine as he instructed me (MORNING and EVENING) and i was
    cured! its really like a dream but i'm so happy! That’s the reason i
    decided to also add more comment of Him so that more people can be saved
    just like me! and if you need his help ,contact his Email: ( Drgodwin
    homeofsolution@gmail.com ) you can massage
    him on whatsapp @ +2348054615060

    ReplyDelete
  27. i already gave up on ever getting cured of HSV2 because i have try many treatment none of them work out for me i have go to different hospital they always tell me same thing there is no cure for herpes when i came across a post about Dr ohunyom, in the net from a lady called Angela i contacted him and he reassured me with him herbal medicine which i took according to the way he instructed, that how i was cured. I doubted at first because i have been to a whole lot of reputable doctors, tried a lot of medicines but none was able to cure me. so i decided to listen to him and he commenced treatment, and under two weeks i was totally fee from #Herpes. i want to say a very big thank you to DR ohunyom for what he has done in my life. feel free to leave him a message on email drohunyom@gmail.com and also WhatsApp him +2349060579973..
    He can still be able to help you with this herbs medicine:
    1...ALS CURE/DIABETES CURE/EPILESY/HPV CURE/LUPUS/HEPATITIS/CANCER/GOUT      

    ReplyDelete
  28. I Want To Appreciate Dr.OYAGU for hs great deeds, I Was Diagnosed With type 2 Herpes Virus Last year,And Was Look For Solution To Be Cured Luckily I Saw Testimonies On How Dr.OYAGU Cure Herpes Virus I Decided To Contact Dr.OYAGU I Contacted Him He Prepared A Herbal Medicine Portion And Sent It To Me,I Started The Herbal Medicine For My Health.He Gave Me Step By Step Instructions On How To Apply It, When I Applied It As Instructed, I Was Cured Of This Deadly Herpes Within 2 weeks, I Am Now Herpes Negative.My Brother And Sister I No That There Are So Many People That Have There Same Herpes Virus Please contact Dr OYAGU To Help You Too,And Help Me To Thank Dr.OYAGU For Cure Me, I’m Cured By Dr. OYAGU Herbal Medicine,His Contact Email:oyaguspellcaster@gmail.com

    Or Cell Whatsapp Number +2348101755322 thank you .....

    ReplyDelete
  29. i want to inform the public how i was cured of HERPES Simplex Virus by a Doctor called Dr.EBHOTA. i visited different hospital but they gave me list of drugs like Famvir, Zovirax, and Valtrex which is very expensive to treat the symptoms and never cured me. I was browsing through the Internet searching for remedy on HERPES and i saw comment of people talking about how Doctor EBHOTA cured them. I Was scared because i never believed in the Internet but i was convince to give him a try because i was having no hope of been cured of HERPES so i decided to contact him on his email, i searched his email on net and i saw a lot of people testifying about his goodness. when i contacted him he gave me hope and send a Herbal medicine to me that i took and it seriously worked for me, am a free person now without problem, my HERPES result came out negative. You can contact him on
    his Email: drebhotasolution@gmail.com or whatsapp him on +2348089535482 and get all your problem solved.
    1Sickness of any kind
    2 Help to CURE Hepatitis B, HIV/AIDs CANCER and BIPOLAR
    3 Divorce, Breakup problem and To Re-unit
    4 Pregnancy problem
    5 Financial problem and Job promotion
    6 To get a good and rich life partner
    7 To Lose your wath
    8 to enlargement of pennis
    9. CANCER
    10. ALS (Lou Gehrig's disease)
    11 Hepatitis B
    12 chronic pancreatic
    13 emphysema
    14 COPD (chronic obstructive pulmonary disease)   

    ReplyDelete
  30. I Want To Appreciate Dr.OYAGU for hs great deeds, I Was Diagnosed With type 2 Herpes Virus Last year,And Was Look For Solution To Be Cured Luckily I Saw Testimonies On How Dr.OYAGU Cure Herpes Virus I Decided To Contact Dr.OYAGU I Contacted Him He Prepared A Herbal Medicine Portion And Sent It To Me,I Started The Herbal Medicine For My Health.He Gave Me Step By Step Instructions On How To Apply It, When I Applied It As Instructed, I Was Cured Of This Deadly Herpes Within 2 weeks, I Am Now Herpes Negative.My Brother And Sister I No That There Are So Many People That Have There Same Herpes Virus Please contact Dr OYAGU To Help You Too,And Help Me To Thank Dr.OYAGU For Cure Me, I’m Cured By Dr. OYAGU Herbal Medicine,His Contact Email:oyaguspellcaster@gmail.com

    Or Cell Whatsapp Number +2348101755322 thank you .....

    ReplyDelete
  31. i want to inform the public how i was cured of HERPES Simplex Virus by a Doctor called Dr.EBHOTA. i visited different hospital but they gave me list of drugs like Famvir, Zovirax, and Valtrex which is very expensive to treat the symptoms and never cured me. I was browsing through the Internet searching for remedy on HERPES and i saw comment of people talking about how Doctor EBHOTA cured them. I Was scared because i never believed in the Internet but i was convince to give him a try because i was having no hope of been cured of HERPES so i decided to contact him on his email, i searched his email on net and i saw a lot of people testifying about his goodness. when i contacted him he gave me hope and send a Herbal medicine to me that i took and it seriously worked for me, am a free person now without problem, my HERPES result came out negative. You can contact him on
    his Email: drebhotasolution@gmail.com or whatsapp him on +2348089535482 and get all your problem solved.
    1Sickness of any kind
    2 Help to CURE Hepatitis B, HIV/AIDs CANCER and BIPOLAR
    3 Divorce, Breakup problem and To Re-unit
    4 Pregnancy problem
    5 Financial problem and Job promotion
    6 To get a good and rich life partner
    7 To Lose your wath
    8 to enlargement of pennis
    9. CANCER
    10. ALS (Lou Gehrig's disease)
    11 Hepatitis B
    12 chronic pancreatic
    13 emphysema
    14 COPD (chronic obstructive pulmonary disease)   

    ReplyDelete

  32. I'm here to testify about the great work Dr okosun did for me. I have been suffering from (HERPES) disease for the past 4 years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulating all over my body and i have been taking treatment from different doctors, few weeks ago i came across lots of testimonies from different people on a particular doctor on the internet called Dr okosun on how he cured various people from Herpes Simplex Virus and other diseases. i took the email address of this man from one of the testifiers advising anybody to contact him for help for any kind of sickness that he would be of help, so I emailed him telling him about my (HERPES Virus) he told me not to worry that i was going to be cured! , well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as Dr okosun assured me that i will be cured,after four week of taking his medication as told by dr okosun, i went to my doctor for herpes virus check up and behold i was declared negative, i also waited for a week and went to another hospital for another check up to be be truly sure and behold i was still declared herpes negative, And i want to use this opportunity to tell those people out there secretly suffering from herpes or other diseases should contact dr okosun and get cured. you can get in touch with this doctor via email : drokosun55@gmail.com. You can also whatsapp him +2348124363791. Thanks once again Dr okosun god bless you



    ReplyDelete
  33. May God bless dr.idowu. for his marvelous work in my life, I was diagnosed of HERPES VIRUS, since 2017 and I was taking my medications, I wasn't satisfied with it because i needed to get the{cold score}  HERPES VIRUS, Out of my system, I searched about some possible cure for{cold score} Herpes  i saw comments about Dr.idowu how he cured people's diseases with his herbal medicine, I contacted him and he guided me. I asked for solutions, he stated the remedy for my health, he sent me the medicine through UPS SPEED POST. I took the medicine as prescribed by him and 14 days later i was cured from {cold score} HERPES, thank you so much and you are the one that God sent to change my miserable life, may the almighty GOD be with you all the days of your life, so my brothers and sisters, I ugh you to contact him on this email address if you need his help   Dr.idowuherbalhome@gmail.com .Dr idowu ONCE AGAIN THANK YOU SIR.He also told me that he has solution for the flowing. (+2348052789941) on Whats-app now*fibroid *kidney*fatty liver *HIV/AIDS**..1 Cancer cure Diabetes cures Ringing ear 4 Herpes cures Warts cure HPV cure Get your ex backs Pregnancy herbal medicines Prostate enlargement Hepatitis B 11 Disability Etc. Add him on Whats-app .now add him on via .(+2348052789941) or (+2348052789941). +2348052789941.. .good luck ...save life. you can contract if you have any probelem .............

    ReplyDelete
  34. May God bless dr.idowu. for his marvelous work in my life, I was diagnosed of HERPES VIRUS, since 2017 and I was taking my medications, I wasn't satisfied with it because i needed to get the{cold score}  HERPES VIRUS, Out of my system, I searched about some possible cure for{cold score} Herpes  i saw comments about Dr.idowu how he cured people's diseases with his herbal medicine, I contacted him and he guided me. I asked for solutions, he stated the remedy for my health, he sent me the medicine through UPS SPEED POST. I took the medicine as prescribed by him and 14 days later i was cured from {cold score} HERPES, thank you so much and you are the one that God sent to change my miserable life, may the almighty GOD be with you all the days of your life, so my brothers and sisters, I ugh you to contact him on this email address if you need his help   Dr.idowuherbalhome@gmail.com .Dr idowu ONCE AGAIN THANK YOU SIR.He also told me that he has solution for the flowing. (+2348052789941) on Whats-app now*fibroid *kidney*fatty liver *HIV/AIDS**..1 Cancer cure Diabetes cures Ringing ear 4 Herpes cures Warts cure HPV cure Get your ex backs Pregnancy herbal medicines Prostate enlargement Hepatitis B 11 Disability Etc. Add him on Whats-app .now add him on via .(+2348052789941) or (+2348052789941). +2348052789941.. .good luck ...save life. you can contract if you have any probelem .............

    ReplyDelete
  35. I Never believed i was ever going to be HSV FREE again, DR.Ehiaguna has given me reasons to be happy, i was HSV positive for 2 years and all the means and medicine i tried for treatment was not helpful to me, but when i came on the Internet i saw great testimony about DR.Ehiaguna on how he was able to cure someone from HSV 2, this person said great things about this man, and advice we contact him for any Disease problem that DR.Ehiaguna can be of help, well i decided to give him a try, he requested for my information which i sent to him, and he told me he was going to prepare for me a healing portion, which he wanted me to take for days, and after which i should go back to the hospital for check up, well after taking all the treatment sent to me by DR.Ehiahuna , i went back to the Hospital for check up, and now i have been confirmed HSV NEGATIVE, friends you can reach DR.Ehiaguna on any treatment of any Disease cos i saw many testimony of different disease like, HEPATITIS,HIV AIDS,EPILEPSY, CANCER,CFS he is the one only one i can show you all up to, reach him on drehiaguna@gmail.com or whatsApp him now +2348073908953. quick contact him for help and you can just quickly drop your number on your first mail as i did for easily conversation

    ReplyDelete