Illumina (one of the major DNA sequencing technology companies) announced their newest line sequencing machines. The two new DNA sequencers are the NextSeq 500 and the HiSeq X10, with the NextSeq 500 being marketed for everyday laboratory use, and the HiSeq X10 being marketed as a factory level, population sequencer (this is the higher power model). These are going to be powerful, state-of-the-art machines that are going to have a significant impact on both research and clinical applications. Here I am going to briefly cover what these new machines are and what their release means for contemporary research and clinical applications. As always, I will also point you in the right direction for further reading, in case you are interested in more.
Saturday, January 18, 2014
Sunday, January 12, 2014
A few days ago our lab, in collaboration with some folks here at the Hospital of the University of Pennsylvania Orthopaedics Department, published a manuscript in the Journal of Orthopedic Research. The title of our manuscript was "Culture-independent pilot study of microbiota colonizing open fractures and association with severity, mechanism, location, and complication from presentation to early outpatient follow-up". This is a report of our ongoing prospective study in which we are characterizing the microbial communities associated with open fracture wounds and their adjacent healthy skin, as well as describing correlations between the microbiome and clinical factors (such as healing complications and wound severity). Unfortunately this paper is not open access, so you are going to have to access it through a university or local library subscription to the journal.